SafeGene — Five-Engine Genetic Screening Ledger

SafeGene {{ t.kicker }}

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{{ liveLabel }} {{ t.noIdentifiable }}

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{{ t.openSources }}

rest.ensembl.org {{ ensemblState }}

myvariant.info {{ myvariantState }}

{{ t.records }} ClinVar · gnomAD · 1000G

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SOURCE {{ stampSource }}

STATE {{ stampState }}

LIMIT {{ stampLimit }}

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{{ row.k }} {{ row.v }}

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ENGINE 01

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LIMIT {{ t.e1Limit }}

ENGINE 02

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carriers = 2pq · affected = q²

q · {{ t.alleleFreq }}{{ qDisplay }}

2pq · {{ t.carrierFreq }}{{ carrierFreq }}

q² · {{ t.popAffected }}{{ qSquared }}

{{ carrierFreq }}

{{ hwLabel }}

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LIMIT {{ t.e2Limit }}

ENGINE 03

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{{ t.live }}

P = q²(1 − F) + qF

F · {{ t.relationship }}

q²(1 − F){{ termIndep }}

qF{{ termIbd }}

{{ popRisk }}

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{{ amplification }}

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{{ consanguinityWarn }}

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LIMIT {{ t.e3Limit }}

ENGINE 04

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{{ t.researchIndex }}

S(G) = exp(−Σ wᵢ Pᵢ γᵢ)

w · {{ t.weight }} {{ wDisplay }}

γ · {{ t.severity }} {{ gDisplay }}

{{ safetyIndex }}

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LIMIT {{ t.e4Limit }}

ENGINE 05

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CITED TABLE · NOT LIVE

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{{ t.condLabel }} {{ t.ageLabel }} {{ ageDisplay }}

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{{ t.specLabel }} {{ specDisplay }}

{{ ppvDisplay }}

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{{ falsePosShare }}

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SOURCE {{ t.e5Source }}

LIMIT {{ t.e5NewLimit }}

ENGINE 06

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CITED EMPIRIC · NOT LIVE

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SOURCE {{ t.dm6Source }}

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{{ t.localProcessing }} {{ formatLabel }}

{{ localName }} {{ localCount }}

{{ gateNote }}

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{{ t.decisionTitle }}

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